Ghost of a Chance is the essence of what it is to be a Star Trek: Voyager book. It's a light, quick little adventure with a few of the typical Star Trek moral quandaries thrown in. This one deals primarily with the prime directive and the role of the federation as peacekeepers/protectors.
It's basically an average episode of season one of Voyager which is to say that it isn't bad but it isn't particularly edge of your seat either. It's TV monster of the week stuff. The crew shows up and encounters a problem and then through the use of team work/ingenuity they resolve the problem. 

I would not recommend this to anybody who isn't familiar with Voyager. As somebody who watched the show, I could picture most of the characters in my head. But for somebody who wasn't familiar with the source material, I think you'd be confused or miss what a lot of the technobabble is about. Honestly though, I don't think anybody would be attracted to a book like this unless they were already a Voyager fan. In that case, read it in a few sittings on a lazy afternoon and then forget about it later.