'Appleseed' covers three timelines. Chronologically, we have two brothers who act as forerunners to Western settlement of what will be Ohio. The brothers forge ahead, planting orchards of apples just a few years ahead of others. For one brother this means future profit, somehow. For the other it means salvation. I should mention he is a faun. The second timeline is not so far ahead of our present-day. The world is ravaged with climate change and a corporation has been sold control of wide swathes of the warming continent as the failing United States government evacuates people into remaining temperate zones. A small group of people put up a fight for freedom and the environment. The last is set in distant future where the continent has been inexplicably covered in an ice sheet. A lone being crosses the ice ekking out a diminishing existence. 

These stories come together to form a bleak picture for humanity, but an overall hopeful one for the planet. I personally loved the journey despite liking only one of the characters. This is climate fiction. I don't see any room for a traditional happy ending...and, well, I have to be okay with that.